A basic drug has a pk, (for its conjugate acid) of 8.66. Calculate what percentage will be protonated at pH 7.06. Give your answer to 2 decimal places. Give the numerical answer only; you do not need to include “%” in your answer. The Protonation of Basic Drugs at pH 7.06

Basic Drugs are Protonated at pH 7.06
You can find drugs in either a protonated or deprotonated state depending on your environment. A key factor for determining what percentage of drug will be protonated at any given pH is the pK. This is the measurement of an acidity (or basicity) of a compound. The percentage of basic drugs with a pK 8.66 can be used to calculate the protonation rate at pH 7.06. The Henderson-Hasselbalch equation can be used to solve for the percentage of a drug that is protonated at a given pH (Fine, 2017). The equation can be expressed as pH = pK+ log[Drug Protonated]/[Drug Deprotonated]). The equation below can be used to calculate how much of the drug is protonated at pH 7.06. [Drug Protonated]/[Drug Deprotonated] ratio. The ratio can be then converted into a percentage. Using the Henderson-Hasselbalch equation, the … Cont…
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