A particular mutation (permanent change to DNA) results in the production of an insulin A chain (Figure 12.13) in which one of the Cys residues involved in a disulfide bridge is replaced by a Tyr residue. This mutation, which produces insulin with one less disulfide bond than normal, leads to diabetes and pancreatic disease. Insulin has three disulfide bonds. Which is most likely, that the missing disulfide bond affects only the tertiary structure of the B chain, that it affects only the quaternary structure of insulin, or that it affects both? Explain.
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