AIB1, a member of the steroid receptor co-activator family, is amplified in some breast cancers. Explain how this amplification may alter steroid-dependent breast cancers. Be specific on mechanism of action. Role of AIB1 Amplification in Steroid-Dependent Breast Cancers

Role of AIB1 Amplification in Steroid-Dependent Breast Cancers

AIB1, or Activator Interactor-1, is a member of the steroid receptor co-activator family, and its amplification has been observed in some breast cancers. Studies have demonstrated that AIB1 amplification can affect the progression of steroid-dependent breast cancers.
AIB1 works by binding and activating steroid receptors. By amplifying AIB1, the activation of steroid receptors is increased, leading to increased expression of steroid-dependent genes. This in turn can lead to an increase in the proliferation, survival and metastatic ability of the cancer cells (Rudy et al., 2016). Furthermore, AIB1 amplification has been found to increase steroid sensitivity in breast cancer cells, meaning that a smaller dose of hormonal therapy is needed for the same effect (Du et al., 2020). This could be beneficial for patients, as it may reduce the side effects of the treatment. In addition, AIB1 has been found to regulate the expression of other genes involved in cancer, such as those involved in cell cycle progression and DNA damage repair (Li et al., 2019). By amplifying AIB1, these processes may be altered, potentially leading to an increase in the aggressiveness of the cancer. Cont…

Place your order
(550 words)

Approximate price: $22

Calculate the price of your order

550 words
We'll send you the first draft for approval by September 11, 2018 at 10:52 AM
Total price:
$26
The price is based on these factors:
Academic level
Number of pages
Urgency
Basic features
  • Free title page and bibliography
  • Unlimited revisions
  • Plagiarism-free guarantee
  • Money-back guarantee
  • 24/7 support
On-demand options
  • Writer’s samples
  • Part-by-part delivery
  • Overnight delivery
  • Copies of used sources
  • Expert Proofreading
Paper format
  • 275 words per page
  • 12 pt Arial/Times New Roman
  • Double line spacing
  • Any citation style (APA, MLA, Chicago/Turabian, Harvard)

Our guarantees

Delivering a high-quality product at a reasonable price is not enough anymore.
That’s why we have developed 5 beneficial guarantees that will make your experience with our service enjoyable, easy, and safe.

Money-back guarantee

You have to be 100% sure of the quality of your product to give a money-back guarantee. This describes us perfectly. Make sure that this guarantee is totally transparent.

Read more

Zero-plagiarism guarantee

Each paper is composed from scratch, according to your instructions. It is then checked by our plagiarism-detection software. There is no gap where plagiarism could squeeze in.

Read more

Free-revision policy

Thanks to our free revisions, there is no way for you to be unsatisfied. We will work on your paper until you are completely happy with the result.

Read more

Privacy policy

Your email is safe, as we store it according to international data protection rules. Your bank details are secure, as we use only reliable payment systems.

Read more

Fair-cooperation guarantee

By sending us your money, you buy the service we provide. Check out our terms and conditions if you prefer business talks to be laid out in official language.

Read more