Define toxicity, absorption and distribution. (15%) b. Describe how the physicochemical properties of benzene would affect its absorption and distribution in the body. (15% Toxicity, Absorption, and Distribution: An Overview

Toxicity, Absorption, and Distribution: An Overview

Toxicity, absorption, and distribution are three key ideas within the research of pharmacology. Toxicity is the extent of hurt a substance could cause to an organism at a given dose (Kumar et al., 2019). Absorption is the method of a drug getting into the bloodstream and being transported to tissues and organs the place it has an impact (Yang et al., 2016). Distribution is the method of a drug or different substance transferring by means of the physique, together with the motion of drug molecules from the bloodstream to tissues and organs the place it has an impact (Liu et al., 2020). These three ideas are important to understanding how medication work together with the physique. A drug’s toxicity is determined by the dose, the route of administration, the goal tissue, and different elements. The speed and extent of absorption of a drug rely upon its solubility within the gastrointestinal tract, the pH of the gastrointestinal tract, and the speed at which it’s metabolized (Kumar et al., 2019). The distribution of a drug entails the transport of drug molecules to focus on tissues and organs, and might be affected by the drug’s lipophilicity, its protein binding, and different elements (Liu et al., 2020). Cont…

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