The Phases of B-Cell Activation: From Antigen Recognition to Memory B-Cell Formation
The activation of B cells is a complex and dynamic process that begins with the recognition of an antigen and ends with the formation of memory B cells. This process can be divided into four main phases. The first phase is antigen recognition, in which B cells recognize specific antigens by their surface receptors. This recognition activates the B cells, causing them to secrete a variety of immunoglobulins, including IgM and IgD antibodies. Once the B cell has been activated, it begins to proliferate and differentiate into an effector B cell.
The second phase is the differentiation and proliferation of the B cells. During this phase, the B cells further differentiate into plasma cells, which produce large amounts of antibodies, and memory B cells, which are long-lived and can respond quickly to antigens they have encountered before.
The third phase is the maturation of the memory B cells. This involves the formation of long-lived memory B cells, which have the ability to recognize antigens they have encountered before, and to rapidly respond to them. Cont…..
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