Describe the situation where RNA polymerase transcription is paused. Include in your answer what induces the pausing, why is pausing needed and what occurs after the pause; include important region(s) of RNA polymerase that contribute to the pausing mechanism. Finally, hypothesize what would happen if pausing does not occur. The Dynamics of RNA Polymerase Transcriptional Pausing

Dynamics of RNA Polymerase Transcriptional Pausing
The transcription of RNA polymerase is an essential step in gene expression. It is also necessary for the production and maintenance of proteins. This involves binding RNA polymerase at the promoter of a gene, and then transcription of that gene’s sequence of DNA into an mRNA molecular. Sometimes, though, polymerase might pause during transcription. This is caused by special structures found within DNA, known as “pause sites”, which can contain sequences that could interfere with the transcription process. This is an essential step in gene regulation. This allows cells to adjust to changing environmental stimuli or conditions by changing the transcription rate. The cell can pause to evaluate the situation, determine whether or not the gene should go into expression. By changing the conformation of the polymerase to pause transcription, the cell can interact with specific proteins at the pause location. These proteins may then be used to induce or stop transcription depending on cell conditions. Cont…
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