Desmosomes are proteins that act as adhesive junctions between cells in the stratum basale layer of the skin. These proteins are essential for the formation of a strong cell-to-cell bond which allows the cells to remain intact and attached to each other on the upper and lateral surfaces of the skin. This protein-based connection allows the cells to form a strong barrier that prevents dehydration and irritants from entering the deeper layers of the skin. Desmosomes are made out of cadherins, which are proteins that allow cells to attach to each other and form strong bonds without the need for additional adhesives. Cadherins are composed of calcium ions, which are responsible for cell-to-cell adhesion. Additionally, desmosomes contain proteins such as plakoglobins, desmoplakins, and desmogleins which form the core of the desmosomes and give them their strength (Holbrook & Zhu, 2016). Desmosomes are essential for the structural integrity of the stratum basale layer of the skin as they provide it with a strong bond between the cells. This bond not only prevents dehydration but also protects the (Saijo et al., 2020). Cont…
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