The Role of Lymph Nodes in a Bacterial Peripheral Tissue Infection
The lymph nodes are important components of the lymphatic system and play a major role in the immune system. During a bacterial infection of the peripheral tissue, the lymph node functions to evoke a tailored humoral immune response against the bacterium. When a pathogen invades the body, it is detected by cells of the immune system, such as macrophages and dendritic cells. These cells then travel to the lymph node, where they present antigens from the pathogen to B cells, which activate and proliferate. The activated B cells differentiate into plasma cells that are then released into the bloodstream to produce antibodies against the pathogen (Baronsky et al., 2016). In addition to producing antibodies, the lymph nodes also stimulate the production of white blood cells, such as T cells, which are critical for eliminating infected cells in the body. T cells that encounter the pathogen in the lymph node activate and produce cytokines, which then travel to the site of infection, promoting a stronger immune response (Kaech et al., 2002). Cont…
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