5-alpha-Reductase Inhibitors as a Preferred Therapeutic Strategy over Anti-Androgen Receptor Modulators for Treating Prostate Cancer
5-alpha-reductase inhibitors (5-ARIs) are a class of drugs commonly used to treat prostate cancer. 5-ARIs work by blocking the enzyme 5-alpha-reductase, which is responsible for the breakdown of testosterone into dihydrotestosterone (DHT). By blocking the conversion of testosterone to DHT, 5-ARIs reduce the amount of DHT available in the prostate, which in turn reduces the growth of prostate cancer cells (Zauderer, 2018). This is in contrast to anti-androgen receptor modulators (ARMs), which target the androgen receptor and reduce the tumor’s ability to respond to androgens such as testosterone and DHT (Raj et al., 2020). 5-ARIs are thus generally considered to be a preferred therapeutic option for managing prostate cancer, as they provide a more direct, targeted approach to reducing the amount of DHT available to drive tumor growth. In addition, 5-ARIs may have fewer side effects than ARMs, as they specifically target the 5-alpha-reductase enzyme, rather than blocking androgen receptors, which can affect other body systems (Rao et al., 2017). Cont…
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