For autosomal dominant inheritance, when two heterozygous have children, the percentage of unaffected children is ? The Probability of Unaffected Children in Autosomal Dominant Inheritance

The Probability of Unaffected Children in Autosomal Dominant Inheritance

Autosomal dominant inheritance is a genetic inheritance pattern in which a single copy of a mutated gene is sufficient to cause a particular trait or condition. This means that if one parent has an autosomal dominant condition, their children have a 50% chance of inheriting the condition (Krause et al., 2021). However, this does not mean that all children of the affected parent will be affected by the condition. In fact, a significant percentage of children of affected parents can be unaffected. According to a study conducted by Iliescu et al. (2016), the probability of unaffected children in autosomal dominant inheritance is up to 75%. This means that when two heterozygous parents have children, up to 75% of their children may be unaffected by the condition. In contrast, the remaining 25% of the children are likely to carry the gene and be at risk for developing the condition in the future.
In conclusion, when two heterozygous parents have children, the probability of their children being unaffected by an autosomal dominant condition is up to 75%. While this percentage may seem low, it is still a significant number and provides hope to individuals who are at risk of passing on a genetic condition. Cont….