Arsenic and Glucose-Stimulated Insulin secretion: The Effect of Arsenic
A naturally occurring element Arsenic has been shown to reduce glucose-stimulated insulin production, which is a critical factor in diabetes development. There are two types of arsenic: organic and inorganic. Both can cause insulin secretion to decrease. Research has shown both organic and inorganic arsenic may reduce insulin production by decreasing the expression genes that are related to glucose metabolism. Arsenic may also reduce insulin sensitivity by reducing the ability of pancreatic cells to respond to glucose stimuli (Khan and al. 2018, 2018). Arsenic may also inhibit insulin production by blocking the conversion of proinsulin into insulin in the pancreas. The increased levels of proinsulin can result in an increase in blood sugar. It can lead to an increased secretion of glucose to get glucose levels back at normal. Cont….
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