Types of Mutations Resulting in Growth Factor Receptors that can Transform Cells
Mutations are the changes in the genetic material of an organism that manifests in the form of alterations in its physical characteristics, behavior, and even health. Mutations can arise due to various causes, including exposure to ionizing radiation and various chemicals, and viruses, as well as spontaneous errors in the replication of genetic material. One type of mutation can result in the transformation of cells, and this is the alteration of growth factor receptors. There are several types of mutations that can lead to these receptors being altered, and these are briefly discussed below. One type of mutation resulting in growth factor receptor changes is point mutation. Point mutations occur when the base pairs in the genetic material are altered, usually through the substitution of one base for another. This may cause changes in the activity of the receptor, leading to the transformation of the cell. Another type of mutation resulting in growth factor receptor alterations is called transversion. Transversion happens when a purine base is replaced with a pyrimidine base or vice versa. This type of mutation is known to be linked to the transformation of cells (Liang, 2020; Sun, 2019). A third type of mutation that can lead to growth factor receptor changes is chromosomal rearrangements. Chromosomal rearrangements happen when the structure of a chromosome is changed due to deletions, duplications, or changes in the order of the genes. These rearrangements can cause alterations in the activity of the growth factor receptors, leading to. cont…
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