The Citrate Cycle: The Hub of Metabolism
The citrate cycle, also known as the Krebs cycle or tricarboxylic acid cycle, is a series of chemical reactions that occur in the cell’s mitochondria and is considered the hub of metabolism. This cycle allows organisms to generate energy from food molecules, extract carbon atoms for use in biosynthetic processes, and produce a variety of key intermediates. Here are three reasons why the citrate cycle is considered the hub of metabolism: Firstly, the citrate cycle is central to energy metabolism as it allows cells to generate ATP, the currency of energy in cells (Vesper et al. 2016). This cycle is the primary place where cells oxidize organic molecules, such as fatty acids and carbohydrates, to generate ATP (Lam et al. 2018).
Secondly, the citrate cycle is essential in the generation of precursors for biosynthetic processes, such as anabolic and gluconeogenesis pathways (Vesper et al. 2016). The cycle provides precursors for various biosynthetic pathways (Kumar et al. 2020) and is responsible for replenishing intermediates for amino acid, fatty acid, and cholesterol biosynthesis (Lam et al. 2018). Cont….
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