Mark all correct statements about protein solubility. (mark all that apply) A Sodium chloride is commonly used as salt for precipitation of proteins. B Proteins are least soluble when the pH of the solution is adjusted to their isoelectric point and their solubility increases when the pH is adjusted away from their isoelectric point Protein Solubility: An Overview

Protein Solubility: An Overview

In determining whether a protein is effective in a biological system, it’s important to consider its solubility. The ability to dissolve a protein in water or in solution is called protein solubility. This is the measure of how much protein remains in solution. It can also be used to assess the stability, activity and ability of proteins to interact with other molecules. Some proteins are more liquid than others. It can also depend on how the protein is structured. Hydrophobic proteins, such as methionine or cysteine, have lower solubility and are therefore more hydrophobic. Hydrophilic amino acid proteins, like lysine and arginine tend to have higher solubility and are more hydrophilic. The pH of the solution also has an impact on protein solubility. More acidic solutions can result in decreased solubility (Kumar & Singh, 2020). Cont….

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