pick out some evidence and explain why it suggests condensation is NOT required for the activity of TDP43 Evidence Suggesting TDP43 Activity Does Not Require Condensation

TDP43 Activity does not require condensation according to the evidence

TDP43 (a protein responsible for the regulation of gene transcription, splicing and expression) has been implicated in many neurodegenerative conditions, including amyotrophic lateral sclerosis and frontotemporal dementia (FTD). Although much has been accomplished to determine the role TDP43 plays in these conditions, there are still many unanswered questions. TDP43 activity may require condensation. Recent evidence suggests that TDP43 activitiy does not need condensation. Researchers used a unique approach in order to investigate TDP43 activities. In fact, they found the protein active and functional in absence of condensation in a 2020 paper. The protein could bind to DNA even though it was not condensed. TDP43 activation does not need condensation.
Researchers used cryoelectron microscopy in a 2018 study to analyze the structure and function of TDP43. This indicates that TDP43’s activity is not dependent on condensation. Cont…..