The Regulation of Gene Expression by Environmental Stimuli: A Focus on the Nrf2-ARE Pathway
Gene expression is the process by which genetic information is converted into proteins and other functional molecules. Environmental stimuli can alter gene expression in many ways, such as through the activation of signaling pathways or epigenetic modifications. One example of this is the Nrf2-ARE pathway, which is activated by environmental stressors such as ultraviolet (UV) radiation and oxidative stress (Hassan, 2020). The Nrf2-ARE pathway is a transcriptional regulatory system that responds to environmental stressors by upregulating the expression of a variety of cytoprotective and antioxidant genes (Yoon et al., 2017). When exposed to an environmental stressor, Nrf2 is released from its inhibitory complex and translocates to the nucleus where it binds to antioxidant response elements (AREs) that are present in the promoters of target genes (Hassan, 2020). This leads to the upregulation of those genes and the production of cytoprotective and antioxidant proteins (Yoon et al., 2017). The Role of Nrf2 in Regulating the Expression of Genes in Response to Environmental Stressors
. The gene Nrf2 (Nuclear factor erythroid 2-related factor 2) plays an important role in regulating the expression of genes in response to environmental stressors. Nrf2 is a transcription factor that is activated when exposed to an environmental stressor. Cont….
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