Roughly, proteins possess a density of 1.3 g/cm3. Suppose a protein is a dimer with each monomer containing about 300 amino acids. Approximately what overall shape would you expect the protein to possess, if when it binds to DNA it makes contact in four adjacent major grooves of the DNA all located on one side of the helix? That is, the protein does not reach around the cylinder to make contacts on the back. Can the protein be spherical or must it be highly elongated?
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