The Value of BLT Humanized Mice in CRISPR Testing
|Testing CRISPR gene-editing technologies in BLT (bone marrow, liver, thymus) humanized mice is a step above testing it in a transgenic mouse that contains replication-incompetent proviral HIV due to the more accurate representation of human physiology. This is because BLT mice are engineered to contain human hematopoietic stem cells (HSCs) and human immune cells, allowing them to better mimic the immune response of humans compared to transgenic mice that only contain replication-incompetent proviral HIV (Mendes et al., 2021; Chen et al., 2019). This improved accuracy increases the likelihood of success when transitioning from preclinical trials to clinical trials, providing a greater chance of success for CRISPR treatments. BLT (bone marrow, liver, thymus) humanized mice contain functional human immune systems and can be infected with HIV, making them a more realistic model for studying HIV infection and potential therapies. In contrast, transgenic mice that contain replication-incompetent proviral HIV do not have functional human immune systems and cannot be infected with HIV, limiting their usefulness in studying HIV infection and potential therapies. Cont….
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