Suppose we have a repressor that can prevent the binding of RNA polymerase if it is bound to a site overlapping the RNA poly merasebinding site, and which can completely block the progress of an RNA polymerase if an elongating polymerase runs into it. Why would you expect the effectiveness of the repressor to be higher when its binding site overlaps the polymerase binding site than when its binding site is located at, say, +50? Assume all the relevant kinetic parameters are identical in the two cases.
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