Comprehensive Review: The principal form of Tyrosine at pH 4.
Tyrosine, an important amino acid, plays an important role in many enzymes and proteins. This essential amino acid is becoming more widely studied because of its potential health advantages. It plays an important role in the regulation and production of neurotransmitters and hormones. Tyrosine can be found in dairy products, egg yolks, soybeans, cheese and fish. Tyrosine can be found in both the charged form, Tyrosine H+, and the neutral form, Tyrosine-OH, when it is acidic. Tyrosine-OH dominates at pH 4.5. Numerous studies examined which form is the dominant at pH 4. For example, a study by Díaz et al. The 2016 study by Diaz and colleagues. found that the pH 4.5 dominant form was tyrosineOH, which was stabler than tyrosineH+. The study also showed that tyrosine OH was less soluble than tyrosine H+, and has a greater bioavailability. Azzam and colleagues also found similar results in another study. 2021). A second study by Azzam and colleagues. This showed that at pH 4.5, tyrosineOH was the predominant form of Tyrosine. Additionally, it was stabler than tyrosineH+. Cont…
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