The Hedgehog/Patched Pathway in Melanoma
Melanoma is a type of skin cancer that originates from melanocytes, the cells responsible for skin pigmentation. In recent years, the Hedgehog/Patched (Hh/Ptc) pathway has been identified as a hallmark of melanoma. The Hh/Ptc pathway is a signaling cascade that is involved in regulating cell proliferation, differentiation, and other cellular processes. Mutations in components of this pathway, such as the Hedgehog (Hh) ligand and its receptor, Patched (Ptc), lead to an overactivation of the cell-signaling cascade and a subsequent growth of melanoma cells (Chen and Hung, 2016). Recent studies have focused on how the Hh/Ptc pathway could be used to develop novel therapeutic strategies for melanoma. For instance, researchers have found that inhibition of the pathway, either through small molecules or antibodies, can suppress the growth and survival of melanoma cells (Cardoso et al., 2021). Additionally, there is evidence that suggests that targeting the pathway could be beneficial in combination with other therapies, such as immunotherapy, for the treatment of metastatic melanoma (Weichert et al., 2017). Cont….
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