The nucleotide sequences of two DNA molecules are 5′-CCGATCGGAT-3′ and 5′-TCCGATC-3.’ Can these two molecules form double-stranded DNA (dsDNA)? Can Two DNA Molecules Form Double-Stranded DNA (dsDNA)?

Are Two DNA Molecules able to Form Double-Stranded (dsDNA),?

Double-stranded DNA is formed by complementary base pairings between the two DNA strands. These include 5′-CCGATCGGAT-3 ‘and 5’-TCCGATC-3 ‘. Liu and Zhang (2018) found that the DNA strands must possess complementary bases to be able to create a bond or form a double-helix. These two molecules have bases that aren’t complementary and will therefore not create a dsDNA. It is possible to create a dsDNA through ligation which involves joining two DNA molecules together. This can be achieved in a laboratory and often involves joining two pieces of DNA which have been previously broken up (Aldrich and al., 2019,). To ligate these molecules together, it is necessary to modify the ends of both molecules.
The conclusion is that although these DNA molecules can’t form a single dsDNA, they are capable of being joined together through ligation. In order to make complementary bases, you will need to modify the ends of these molecules. Cont….