Under hypoxic conditions, expression of HIF-????? is increased and HIF-????? elevates the expression of glucose transporters and glycolytic enzymes. The increased expression of these genes is because glycolysis generates ATP production faster than the electron transport chain. true or false? Is Glycolysis the Primary Driver of ATP Production Under Hypoxic Conditions?

Is Glycolysis the Main Driver of ATP Manufacturing Below Hypoxic Circumstances?

It’s true that underneath hypoxic situations, expression of HIF-????? is elevated, and this in flip elevates the expression of glucose transporters and glycolytic enzymes. This improve in expression is regarded as on account of the truth that glycolysis can generate ATP manufacturing quicker than the electron transport chain. It’s because glycolysis is an anaerobic course of, and thus doesn’t require oxygen for ATP manufacturing. Nevertheless, though glycolysis is quicker than the electron transport chain, it isn’t essentially the first driver of ATP manufacturing underneath hypoxic situations. It’s because the electron transport chain doesn’t utterly shut down, and might nonetheless generate ATP throughout hypoxic situations. Moreover, though glycolysis doesn’t require oxygen, it does produce giant quantities of lactic acid, which is then transported to the liver for conversion to glucose. Thus, though glycolysis can generate ATP quicker than the electron transport chain underneath hypoxic situations, this doesn’t essentially make it the first driver of ATP manufacturing. Cont…..

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