Identifying Trinucleotide Repeat Disorders with DNA Testing
Trinucleotide repeat disorders (TRDs) are a group of genetic diseases caused by an expansion of trinucleotide repeats in specific genes. These repeats can cause a variety of neurological and neuromuscular disorders, and three of the most common TRDs are fragile X syndrome, myotonic dystrophy type 1, and Huntington’s disease. DNA testing is the most reliable way to determine if an individual carries one or more defective genes associated with these diseases. Fragile X syndrome is caused by an expansion of CGG trinucleotide repeats in the FMR1 gene, and is the most common inherited form of intellectual disability (Raymond et al., 2020). DNA testing for this disease involves amplifying the FMR1 gene to determine the number of CGG repeats and identify individuals who have the disease-causing mutation.
Myotonic dystrophy type 1 is caused by an expansion of a CTG trinucleotide repeat in the DMPK gene (Kapoor et al., 2017). DNA testing for this disease involves amplifying the DMPK gene to determine the number of CTG repeats and identify individuals who have the disease-causing mutation.
Huntington’s disease is caused by an expansion of CAG trinucleotide repeats in the HTT gene (Liu et al., 2021). DNA testing for this disease involves amplifying the HTT gene to determine the number of CAG repeats and identify individuals who have the disease-causing mutation. Cont…
Delivering a high-quality product at a reasonable price is not enough anymore.
That’s why we have developed 5 beneficial guarantees that will make your experience with our service enjoyable, easy, and safe.
You have to be 100% sure of the quality of your product to give a money-back guarantee. This describes us perfectly. Make sure that this guarantee is totally transparent.Read more
Each paper is composed from scratch, according to your instructions. It is then checked by our plagiarism-detection software. There is no gap where plagiarism could squeeze in.Read more
Thanks to our free revisions, there is no way for you to be unsatisfied. We will work on your paper until you are completely happy with the result.Read more
Your email is safe, as we store it according to international data protection rules. Your bank details are secure, as we use only reliable payment systems.Read more
By sending us your money, you buy the service we provide. Check out our terms and conditions if you prefer business talks to be laid out in official language.Read more