What is the stoichiometry of GTP, ATP, and pyruvate in the production of glucose? Online it says 2 pyruvate, 4 ATP, and 2 GTP, but a tutor says 2 ATP and 1 GTP only. Am confused on which one it is! The Stoichiometry of GTP, ATP and Pyruvate in Glucose Production

The Stoichiometry of GTP, ATP and Pyruvate in Glucose Manufacturing

Glucose manufacturing, or gluconeogenesis, is a course of through which pyruvate and different molecules are transformed into glucose. The method entails the usage of GTP, ATP, and pyruvate, and the precise stoichiometry of those molecules in glucose manufacturing varies relying on the species and the circumstances. Typically, the stoichiometry of GTP and ATP in glucose manufacturing is 1:1, whereas the stoichiometry of pyruvate and glucose is 1:2 (Lodish et al., 2016; Choudhury et al., 2018). Within the gluconeogenesis pathway, GTP and ATP are used to transform fructose-1,6-bisphosphate into fructose-6-phosphate, after which glucose-6-phosphate. As such, the 1:1 ratio of GTP and ATP is required to catalyze this response. Moreover, the pyruvate and glucose response is catalyzed by pyruvate carboxylase, which requires a 1:2 ratio of pyruvate and glucose (Heldt, 2017; Aung et al., 2020). Cont….

The stoichiometry of GTP, ATP and pyruvate within the manufacturing of glucose is crucial to know the pathway of gluconeogenesis.