Which calibration technique is used when there are interference from matrix? Calibration Using Internal Standard Method for Interference from Matrix

Calibration Using Internal Standard Method for Interference from Matrix

When dealing with interference from a matrix, one of the most reliable calibration techniques is the internal standard method. This method involves the addition of a known quantity of an analyte to a sample prior to analysis. The analyte is then measured and compared to the known quantity, allowing for the calculation of the concentration of the analyte in the sample. This method is often used in chromatography, spectroscopy, and other analytical techniques  (Deveau et al., 2018). The advantage of the internal standard method lies in its ability to account for any interference that may be present in the sample matrix. By providing a known reference, the method allows for greater accuracy in the calculation of the analyte’s concentration. An example of this is in liquid chromatography/mass spectrometry (LC/MS) analysis, where the presence of interferences can lead to inaccurate results. By adding an internal standard, LC/MS analysis can be (Kolb et al., 2016). Cont…