The Limitations of Linkage Mapping: The Least Accurate Form of Genetic Mapping
Linkage mapping is a form of genetic mapping that is used to determine the location of genes on a chromosome. It does this by tracing the inheritance of a gene or group of genes through generations of a family. By looking at the patterns of inheritance, it is possible to infer the location of the gene or group of genes within the genome. Despite its utility, linkage mapping is the least accurate form of genetic mapping, providing the lowest resolution between genes. Linkage mapping is limited by the fact that it relies on the inheritance of a gene or group of genes through generations to infer its location. This is due to the fact that recombination or crossover of genetic material between chromosomes can cause genes to be rearranged, making it difficult to accurately pinpoint their exact location. As such, the resolution of linkage mapping is limited to the number of generations that are studied. Additionally, the resolution of linkage mapping can be affected by the presence of close relatives in the family, leading to a lower resolution between genes (Chen et al., 2019; Tawfik et al., 2020). Cont…
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