You have identified a new receptor tyrosine kinase (RTK) which you have designated XAX. XAX has sequence homology to the RTK MET, which has an important role in cancer. You are interested in studying whether XAX is a potentially valuable target against which to develop therapeutics for treatment of cancer patients. Name two tests would you perform to determine which cancers XAX is likely to be relevant in, and what results of these tests would support the decision to pursue XAX. The Role of Novel Receptor Tyrosine Kinase XAX in Cancer Treatment

The Role of Novel Receptor Tyrosine Kinase XAX in Cancer Treatment

Receptor tyrosine kinase (RTK) XAX, which has sequence homology to the RTK MET, has potential to be a valuable target for the development of therapeutics to treat cancer. To determine which cancers XAX is likely to be relevant in, two tests should be performed. The first test is a bioinformatics analysis in which the sequence and structure of XAX are compared to the sequences and structures of other known RTKs. Through this analysis, one can determine if XAX has shared characteristics that could suggest it could play a role in cancers similar to those in which MET is involved (Lam et al., 2016). The second test is a functional analysis, in which XAX is analyzed for its ability to bind to the same ligands as MET, as well as its ability to activate the same downstream intracellular pathways (Takano et al., 2021). Positive results from these tests would indicate that XAX may be a viable target for cancer therapeutics, and could support the decision to pursue XAX for further study and development. Cont…

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